Ammonium transmembrane transport

Across TCGA patient cohorts, RNA activity of the Ammonium transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, TMEM62, and GCLC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium transmembrane transport activity versus SLC12A2 in PDAC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC12A2 →	+0.729	+0.554	<.001	<.001	3	6
BRCA	TMEM62 →	+0.677	+0.269	.001	<.001	3	4
UCEC	GCLC →	+0.906	+0.919	.001	<.001	3	3
UCEC	PERP →	+0.697	+0.849	.003	.002	3	3
OV	SAT1 →	+0.875	+0.590	.001	.002	3	3
UCEC	COLCA2 →	+0.713	+0.792	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072488 vs SLC12A2 — PDAC

Explore this scatter interactively →