Ammonium transmembrane transport

Across TCGA cell cohorts, RNA activity of the Ammonium transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEP1A, PLA2G12B, and S100A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEP1A grouped by Ammonium transmembrane transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MEP1A →	-0.272	-1.062	.006	.007	3	4
STOMACH	PLA2G12B →	+0.148	+1.370	.005	.001	3	4
OVARY	S100A3 →	-0.194	-0.927	<.001	.001	3	4
BREAST	GALNT4 →	+0.108	+0.693	.006	.002	3	4
BLOOD_Myeloma	MLYCD →	-0.296	-0.152	.002	<.001	3	3
BLOOD_Myeloma	ANP32E →	-0.335	-0.152	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEP1A by Ammonium transmembrane transport activity — BLOOD_Leukemia

Explore this box plot interactively →