Ammonium transmembrane transport

Across TCGA cell cohorts, RNA activity of the Ammonium transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, SLC12A5, and TTC7B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium transmembrane transport activity versus SLC12A2 in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC12A2 →	+2.087	+1.187	<.001	<.001	3	10
BONE	SLC12A5 →	+2.810	+1.476	<.001	<.001	3	10
STOMACH	TTC7B →	-1.984	-0.938	<.001	.001	3	7
LARGE_INTESTINE	SLC36A4 →	-0.995	-0.617	.001	.009	3	7
SOFT_TISSUE	CORO1C →	-0.733	-0.742	.004	.007	3	6
SOFT_TISSUE	SERTAD2 →	-0.783	-1.034	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072488 vs SLC12A2 — BREAST

Explore this scatter interactively →