Microtubule anchoring at microtubule organizing center

Across TCGA patient cohorts, RNA activity of the Microtubule anchoring at microtubule organizing center pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFAP36, PFN2, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule anchoring at microtubule organizing center activity versus CFAP36 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CFAP36 →	+0.377	+0.036	<.001	<.001	3	7
HNSC	PFN2 →	+0.481	+0.062	.001	<.001	3	6
GBM	RPL5 →	-0.118	-0.034	.007	.003	3	5
HNSC	MAP1B_S2211 →	+0.636	+0.084	<.001	<.001	3	4
CCRCC	IFT52 →	+0.324	+0.033	<.001	.001	3	4
OV	MAP1B_S937 →	+1.181	+0.086	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072393 vs CFAP36 — CCRCC

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