Microtubule anchoring at microtubule organizing center

Across TCGA cell cohorts, RNA activity of the Microtubule anchoring at microtubule organizing center pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNGA4, VAPA, and SMG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNGA4 grouped by Microtubule anchoring at microtubule organizing center-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CNGA4 →	-0.820	-2.178	.005	<.001	3	4
CNS	VAPA →	-0.540	-0.622	<.001	.003	3	3
CNS	SMG1 →	-0.417	-0.638	.004	<.001	3	3
CNS	KCMF1 →	-0.472	-0.572	.002	.003	3	3
CNS	ARIH2 →	-0.412	-0.689	.001	.009	3	3
CNS	MAP4 →	-0.589	-0.576	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNGA4 by Microtubule anchoring at microtubule organizing center activity — BLOOD_Lymphoma

Explore this box plot interactively →