Microtubule anchoring at microtubule organizing center

Across TCGA cell cohorts, RNA activity of the Microtubule anchoring at microtubule organizing center pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A51, PCM1, and GEM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule anchoring at microtubule organizing center activity versus SLC25A51 in PANCREAS (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC25A51 →	+0.695	+0.517	<.001	<.001	3	5
LUNG_NSCLC_LUAD	PCM1 →	+0.738	+0.355	<.001	.003	3	5
LUNG_NSCLC_LUAD	GEM →	+1.994	+0.257	<.001	<.001	3	5
PANCREAS	KLK6 →	-5.474	-0.452	<.001	<.001	3	5
LUNG_NSCLC_LUSC	SZRD1 →	+1.094	+0.388	.007	.006	3	4
LUNG_SCLC	CCDC171 →	+0.756	+0.773	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072393 vs SLC25A51 — PANCREAS

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