Plus-end-directed organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONP2, BICRAL, and SOS1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plus-end-directed organelle transport along microtubule activity versus LONP2 in UVM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	LONP2 →	+0.988	+0.039	<.001	<.001	3	33
DLBC	BICRAL →	+1.268	+0.066	<.001	<.001	3	33
DLBC	SOS1 →	+1.194	+0.082	<.001	<.001	3	33
THYM	KIAA1109 →	+1.226	+0.068	<.001	<.001	3	33
DLBC	DCAF1 →	+0.835	+0.062	<.001	<.001	3	33
THYM	SHPRH →	+0.906	+0.081	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072386 vs LONP2 — UVM

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