Plus-end-directed organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN8, KIF3A, and KIFAP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plus-end-directed organelle transport along microtubule activity versus SEPTIN8 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN8 →	+0.403	+0.100	<.001	<.001	3	8
BRCA	KIF3A →	+0.234	+0.064	<.001	<.001	3	8
LSCC	KIFAP3 →	+0.217	+0.040	<.001	<.001	3	8
LUAD	NCL_S67 →	-0.774	-0.055	<.001	<.001	3	7
LUAD	RPL12_S38 →	-0.877	-0.045	<.001	<.001	3	7
BRCA	BBS2 →	+0.413	+0.086	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072386 vs SEPTIN8 — GBM

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