Plus-end-directed organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPT, KIF3B, and FYCO1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPT grouped by Plus-end-directed organelle transport along microtubule-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAPT →	-0.318	-0.448	<.001	.005	3	9
STOMACH	KIF3B →	-0.336	-1.453	<.001	<.001	3	7
PANCREAS	FYCO1 →	-0.205	-0.829	.004	.004	3	6
LIVER	UCP2 →	-0.343	-1.336	.008	.002	3	5
LARGE_INTESTINE	ID4 →	-0.228	-1.226	.003	<.001	3	5
STOMACH	HTR5A →	-0.220	-1.602	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPT by Plus-end-directed organelle transport along microtubule activity — KIDNEY

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