Plus-end-directed organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT9, CLCF1, and MYO1E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT9 grouped by Plus-end-directed organelle transport along microtubule-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NUDT9 →	+0.664	+1.130	.006	.001	3	4
BLOOD_Leukemia	CLCF1 →	-1.144	-0.997	.002	.005	3	4
SOFT_TISSUE	MYO1E →	-3.365	-1.477	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MITD1 →	-0.993	-1.491	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CTU2 →	-0.911	-1.546	.002	.001	3	4
BONE	TIMP3 →	-2.450	-1.557	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT9 by Plus-end-directed organelle transport along microtubule activity — STOMACH

Explore this box plot interactively →