Plus-end-directed organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Plus-end-directed organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPT, KDELR1, and CHAF1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plus-end-directed organelle transport along microtubule activity versus MAPT in BONE (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAPT →	+6.362	+2.273	<.001	<.001	3	4
LUNG_SCLC	KDELR1 →	+0.712	+0.540	<.001	.007	3	4
LUNG_SCLC	CHAF1A →	+0.411	+0.364	.004	.008	2	5
BREAST	PABPC3 →	+0.466	+0.443	.009	.005	3	4
OVARY	SMU1 →	+1.013	+0.424	.002	.009	3	3
OVARY	EAF1 →	+0.735	+0.366	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072386 vs MAPT — BONE

Explore this scatter interactively →