Organelle transport along microtubule

Across TCGA patient cohorts, RNA activity of the Organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C2, ATP8B2, and CA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle transport along microtubule activity versus AKR1C2 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C2 →	+1.596	+0.416	<.001	.002	3	4
HNSC	ATP8B2 →	+1.111	+0.346	<.001	.001	3	3
HNSC	CA3 →	+1.578	+0.303	.008	.001	3	3
HNSC	FHL1 →	+2.126	+0.378	.001	<.001	3	3
HNSC	SLIT3-AS2 →	+0.835	+0.338	.008	.004	3	3
HNSC	OSBPL6 →	+1.368	+0.345	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072384 vs AKR1C2 — UCEC

Explore this scatter interactively →