Organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Organelle transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, SUCLG1, and TGFB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle transport along microtubule activity versus SLC2A1 in LARGE_INTESTINE (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC2A1 →	+1.627	+0.187	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SUCLG1 →	-0.791	-0.259	<.001	<.001	3	5
LUNG_SCLC	TGFB1 →	+2.097	+0.180	.002	<.001	2	5
URINARY_TRACT	MOGS →	+0.649	+0.431	.004	.004	3	4
BONE	ABHD4 →	+2.041	+0.194	<.001	.005	3	4
STOMACH	EEF1B2 →	-1.363	-0.297	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072384 vs SLC2A1 — LARGE_INTESTINE

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