Organelle transport along microtubule

Across TCGA cell cohorts, RNA activity of the Organelle transport along microtubule pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BTF3, UBAP2L, and UBE2K, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle transport along microtubule activity versus BTF3 in STOMACH (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BTF3 →	-2.408	-0.384	.008	.006	3	14
LIVER	UBAP2L →	-1.818	-0.253	<.001	<.001	3	14
PANCREAS	UBE2K →	-1.718	-0.332	<.001	<.001	3	14
LIVER	PRRC2C →	-1.220	-0.274	.005	<.001	2	15
PANCREAS	CCT8 →	-1.555	-0.241	.001	.002	3	14
URINARY_TRACT	RPS21 →	-2.098	-0.349	.003	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072384 vs BTF3 — STOMACH

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