"Blood coagulation, fibrin clot formation"

Across TCGA patient cohorts, RNA activity of the "Blood coagulation, fibrin clot formation" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F13A1, MRC1, and MRC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Blood coagulation, fibrin clot formation" activity versus F13A1 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	F13A1 →	+1.025	+0.140	<.001	<.001	3	9
GBM	MRC1 →	+0.857	+0.130	<.001	<.001	3	9
BRCA	MRC2 →	+0.613	+0.066	<.001	<.001	3	9
OV	NNMT →	+1.061	+0.072	<.001	.003	3	9
OV	C1S →	+0.629	+0.084	<.001	<.001	3	9
GBM	STAB1 →	+0.489	+0.109	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072378 vs F13A1 — GBM

Explore this scatter interactively →