"Blood coagulation, fibrin clot formation"

Across TCGA patient cohorts, RNA activity of the "Blood coagulation, fibrin clot formation" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SELENOP, C6, and C8B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Blood coagulation, fibrin clot formation" activity versus SELENOP in CCRCC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SELENOP →	+0.843	+0.771	<.001	<.001	3	9
COAD	C6 →	+0.849	+1.034	<.001	<.001	3	9
UCEC	C8B →	+0.658	+0.610	<.001	.005	3	9
CCRCC	CPN1 →	+0.705	+0.445	<.001	<.001	3	9
BRCA	F13B →	+0.715	+0.220	<.001	<.001	3	9
COAD	FGA →	+1.000	+0.856	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072378 vs SELENOP — CCRCC

Explore this scatter interactively →