"Blood coagulation, fibrin clot formation"

Across TCGA cell cohorts, RNA activity of the "Blood coagulation, fibrin clot formation" pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, LCOR, and ARHGEF7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by "Blood coagulation, fibrin clot formation"-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPP1R12A →	+0.480	+0.402	<.001	<.001	3	8
BREAST	LCOR →	-0.101	-0.271	.006	.003	3	6
PANCREAS	ARHGEF7 →	+0.243	+0.425	<.001	.001	3	6
SKIN	MAX →	-0.195	-0.127	.004	.009	3	6
LARGE_INTESTINE	TEAD1 →	+0.291	+0.242	.002	.001	3	5
PANCREAS	PKN2 →	+0.195	+0.376	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by "Blood coagulation, fibrin clot formation" activity — PANCREAS

Explore this box plot interactively →