"Blood coagulation, fibrin clot formation"

Across TCGA cell cohorts, RNA activity of the "Blood coagulation, fibrin clot formation" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, DDX60L, and ACER2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Blood coagulation, fibrin clot formation" activity versus FN1 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FN1 →	+4.286	+0.308	.002	.007	3	7
PANCREAS	DDX60L →	+1.686	+0.314	.002	.002	3	6
URINARY_TRACT	ACER2 →	-2.252	-0.423	<.001	.004	3	5
LARGE_INTESTINE	HDHD3 →	-1.069	-0.530	.001	.007	3	5
BREAST	SNAPC1 →	+1.199	+0.423	.003	<.001	3	5
PANCREAS	DDX60 →	+1.708	+0.302	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072378 vs FN1 — OVARY

Explore this scatter interactively →