Tricarboxylic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Tricarboxylic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLT1P1, C9orf153, and SLC25A39, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricarboxylic acid metabolic process activity versus FLT1P1 in BRCA (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FLT1P1 →	-0.061	-0.098	.007	.008	3	3
LSCC	C9orf153 →	-0.329	-0.107	<.001	.001	3	3
GBM	SLC25A39 →	+0.324	+0.102	<.001	.001	3	3
OV	GUSBP3 →	+0.270	+0.109	.003	.004	3	3
HNSC	CARD11-AS1 →	+0.433	+0.156	.003	<.001	3	3
PDAC	PDCD5P1 →	-0.263	-0.109	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072350 vs FLT1P1 — BRCA

Explore this scatter interactively →