Tricarboxylic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Tricarboxylic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL38, BORCS7, and IGFBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL38 grouped by Tricarboxylic acid metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRPL38 →	+0.731	+0.325	<.001	.006	3	3
LUNG_SCLC	BORCS7 →	+0.763	+0.379	.002	.008	3	3
BREAST	IGFBP2 →	+2.870	+0.493	.002	.004	3	3
BREAST	ZSWIM5 →	+0.682	+0.381	.001	.001	3	3
SKIN	TXNDC15 →	-0.596	-0.715	.005	.005	3	3
SKIN	SFXN4 →	+0.558	+0.512	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL38 by Tricarboxylic acid metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →