Tricarboxylic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Tricarboxylic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH3A, WHAMM, and ACAA1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricarboxylic acid metabolic process activity versus IDH3A in BREAST (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IDH3A →	+1.113	+0.344	.001	<.001	3	11
BLOOD_Lymphoma	WHAMM →	+0.715	+0.225	.009	.002	3	7
BLOOD_Lymphoma	ACAA1 →	+0.577	+0.195	.008	.008	3	6
LIVER	TMED3 →	+4.960	+0.214	.003	<.001	3	6
LUNG_SCLC	RNASEH2A →	-0.748	-0.237	.001	<.001	3	5
OVARY	HDX →	-1.175	-0.240	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072350 vs IDH3A — BREAST

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