Sulfur compound transport

Across TCGA patient cohorts, RNA activity of the Sulfur compound transport pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC36A1, SLC43A2, and SLC26A6, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound transport activity versus SLC36A1 in LAML (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	SLC36A1 →	+1.048	+0.042	<.001	<.001	3	24
TGCT	SLC43A2 →	+0.714	+0.026	<.001	<.001	3	21
ACC	SLC26A6 →	+1.068	+0.026	<.001	<.001	3	21
ACC	PCK2 →	+1.597	+0.027	<.001	.002	2	20
KICH	SLC7A5 →	+2.651	+0.044	<.001	<.001	3	19
UCS	SLC6A6 →	+1.414	+0.035	<.001	.007	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072348 vs SLC36A1 — LAML

Explore this scatter interactively →