Sulfur compound transport

Across TCGA cell cohorts, RNA activity of the Sulfur compound transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGAT2, TMEM150A, and OGFOD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound transport activity versus DGAT2 in LUNG_SCLC (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DGAT2 →	-1.872	-0.836	.003	.001	3	5
OESOPHAGUS	TMEM150A →	-1.598	-0.294	<.001	.004	3	5
STOMACH	OGFOD3 →	-0.959	-0.464	.001	.005	3	4
LUNG_NSCLC_LUAD	SLC7A5 →	+1.802	+0.312	<.001	.002	3	4
OVARY	SLC3A2 →	+1.592	+0.843	<.001	.005	3	4
SKIN	CAPN5 →	-2.102	-0.288	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072348 vs DGAT2 — LUNG_SCLC

Explore this scatter interactively →