Intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAC9, PPP1R16B, and MRPL24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway by p53 class mediator activity versus PLAC9 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLAC9 →	-0.792	-0.186	<.001	<.001	3	5
GBM	PPP1R16B →	-1.299	-0.223	<.001	<.001	3	4
CCRCC	MRPL24 →	+0.242	+0.088	.001	.009	3	4
CCRCC	PRDM11 →	-0.356	-0.173	.001	<.001	3	4
BRCA	RAPGEF3 →	-0.602	-0.171	.001	.001	3	4
BRCA	ADAMTS10 →	-0.672	-0.160	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072332 vs PLAC9 — BRCA

Explore this scatter interactively →