Intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT3, MSH2, and POLH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMAT3 grouped by Intrinsic apoptotic signaling pathway by p53 class mediator-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZMAT3 →	-1.348	-0.967	<.001	.007	3	5
BLOOD_Leukemia	MSH2 →	+1.124	+0.280	.005	.002	3	4
OESOPHAGUS	POLH →	-1.086	-0.314	.002	<.001	3	3
STOMACH	FKBP3 →	-0.830	-0.219	.008	.002	3	3
STOMACH	ATP6V1D →	-1.038	-0.353	<.001	<.001	3	3
STOMACH	SNX6 →	-1.259	-0.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMAT3 by Intrinsic apoptotic signaling pathway by p53 class mediator activity — SKIN

Explore this box plot interactively →