Intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLFN5, MINK1, and ZNF737, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway by p53 class mediator activity versus SLFN5 in BLOOD_Leukemia (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLFN5 →	+2.204	+0.191	<.001	<.001	3	6
BLOOD_Leukemia	MINK1 →	+0.659	+0.197	.004	<.001	3	5
BLOOD_Leukemia	ZNF737 →	+1.811	+0.172	<.001	.001	3	4
LUNG_NSCLC_LUSC	ZNF486 →	+1.261	+0.296	.004	.005	3	4
OESOPHAGUS	MX1 →	+2.344	+0.289	.004	<.001	3	4
KIDNEY	TRAF4 →	+0.824	+0.206	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072332 vs SLFN5 — BLOOD_Leukemia

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