Signal transduction by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Signal transduction by p53 class mediator pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME8, CSMD1, and PDE4DIPP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NME8 grouped by Signal transduction by p53 class mediator-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NME8 →	-0.202	-0.048	.006	.008	3	4
OESOPHAGUS	CSMD1 →	-0.181	-0.048	.003	.002	3	4
SKIN	PDE4DIPP2 →	+0.195	+0.041	.001	.001	3	4
SKIN	MEOX1 →	-0.175	-0.046	.001	<.001	3	4
BLOOD_Lymphoma	SETD9 →	+0.257	+0.106	<.001	.003	3	3
BLOOD_Lymphoma	DPY30 →	-0.537	-0.109	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NME8 by Signal transduction by p53 class mediator activity — SKIN

Explore this box plot interactively →