Signal transduction by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBBP1A, TSR1, and PML, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction by p53 class mediator activity versus MYBBP1A in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYBBP1A →	+1.462	+0.317	.002	<.001	3	6
LUNG_NSCLC_LUSC	TSR1 →	+0.729	+0.252	.004	.001	3	5
LUNG_NSCLC_LUAD	PML →	+0.808	+0.192	.005	<.001	3	5
BONE	SQOR →	+2.345	+0.239	.002	.001	2	6
LUNG_NSCLC_LUSC	PFN1 →	+2.030	+0.364	.004	<.001	3	4
LUNG_NSCLC_LUSC	MINK1 →	+1.369	+0.356	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072331 vs MYBBP1A — BLOOD_Myeloma

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