Monocarboxylic acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Monocarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D19, CAV2, and ATP10D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D19 grouped by Monocarboxylic acid biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TBC1D19 →	-0.982	-0.884	.005	.003	3	5
OESOPHAGUS	CAV2 →	+1.741	+0.230	.001	<.001	3	4
BLOOD_Lymphoma	ATP10D →	-3.163	-0.433	.001	<.001	3	3
LUNG_NSCLC_LUSC	TRAPPC8 →	+0.905	+0.246	.005	.004	3	3
LUNG_NSCLC_LUSC	LY6G5B →	+0.861	+0.246	.006	.003	3	3
STOMACH	TAS2R19 →	-0.276	-0.239	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D19 by Monocarboxylic acid biosynthetic process activity — SKIN

Explore this box plot interactively →