Monocarboxylic acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Monocarboxylic acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACIR, CEBPZOS, and SMAD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid biosynthetic process activity versus MACIR in LUNG_NSCLC_LUSC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MACIR →	+1.495	+0.376	.006	.003	3	6
CNS	CEBPZOS →	+0.857	+0.180	.002	<.001	3	5
LARGE_INTESTINE	SMAD3 →	-1.297	-0.200	<.001	<.001	3	5
URINARY_TRACT	LAMC2 →	-4.431	-0.298	<.001	.001	3	5
LARGE_INTESTINE	ME2 →	+0.811	+0.164	.002	.001	3	5
BLOOD_Leukemia	RSAD2 →	-1.228	-0.099	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072330 vs MACIR — LUNG_NSCLC_LUSC

Explore this scatter interactively →