Monocarboxylic acid catabolic process

Across TCGA patient cohorts, RNA activity of the Monocarboxylic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECHDC2, LPIN3, and ACCS, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid catabolic process activity versus ECHDC2 in UVM (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ECHDC2 →	+1.156	+0.034	<.001	<.001	3	29
THYM	LPIN3 →	+1.338	+0.028	<.001	<.001	3	27
UVM	ACCS →	+0.810	+0.025	<.001	<.001	3	26
UCS	AMT →	+1.391	+0.028	<.001	<.001	3	26
KIRP	ABHD14A-ACY1 →	+0.327	+0.026	<.001	<.001	3	25
MESO	CLYBL →	+0.835	+0.030	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072329 vs ECHDC2 — UVM

Explore this scatter interactively →