Monocarboxylic acid catabolic process

Across TCGA cell cohorts, RNA activity of the Monocarboxylic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM22, CPE, and FRAT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid catabolic process activity versus SMIM22 in PANCREAS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMIM22 →	+3.763	+0.240	.004	.008	2	7
BREAST	CPE →	+2.516	+0.153	<.001	.001	3	6
BLOOD_Myeloma	FRAT1 →	+1.550	+0.248	.001	.006	3	6
BREAST	FBXO48 →	-0.490	-0.244	<.001	.001	3	6
BREAST	SNRPA →	-0.553	-0.223	<.001	<.001	3	6
PANCREAS	RUVBL1 →	-1.225	-0.355	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072329 vs SMIM22 — PANCREAS

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