Vesicle uncoating

Across TCGA patient cohorts, RNA activity of the Vesicle uncoating pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THADA, COQ10B, and TESPA1_S454, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle uncoating activity versus THADA in UCEC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THADA →	-0.210	-0.049	.001	.009	3	5
UCEC	COQ10B →	+0.458	+0.078	.008	.002	3	5
HNSC	TESPA1_S454 →	+1.580	+0.127	.001	<.001	3	5
LSCC	IGF2BP2 →	-0.655	-0.040	<.001	.001	3	5
LUAD	IRS2_S1100 →	-1.005	-0.052	<.001	.001	3	5
HNSC	ANKRD44 →	+0.339	+0.062	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072319 vs THADA — UCEC

Explore this scatter interactively →