Vesicle uncoating

Across TCGA patient cohorts, RNA activity of the Vesicle uncoating pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSF, FN3K, and TAGLN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle uncoating activity versus NSF in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NSF →	+0.298	+0.613	.008	.002	3	4
OV	FN3K →	+0.486	+0.333	.009	.001	3	3
CCRCC	TAGLN2 →	-0.300	-0.507	<.001	<.001	3	3
LSCC	CLTB →	-0.741	-0.674	<.001	.001	3	3
GBM	SYNGR1 →	+0.702	+0.654	<.001	.003	3	3
GBM	FA2H →	+1.185	+0.671	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072319 vs NSF — BRCA

Explore this scatter interactively →