Vesicle uncoating

Across TCGA cell cohorts, RNA activity of the Vesicle uncoating pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3GL1, DCTN2, and CLTB, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle uncoating activity versus SH3GL1 in URINARY_TRACT (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SH3GL1 →	+1.771	+0.248	.003	.001	3	17
OESOPHAGUS	DCTN2 →	+1.358	+0.205	<.001	<.001	3	15
SOFT_TISSUE	CLTB →	+1.305	+0.224	<.001	<.001	3	15
LIVER	DYNC1I2 →	+1.587	+0.244	.005	.009	3	14
LIVER	NOP56 →	-1.016	-0.210	<.001	.006	2	15
URINARY_TRACT	DBNL →	+2.013	+0.226	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072319 vs SH3GL1 — URINARY_TRACT

Explore this scatter interactively →