Glomerular epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Glomerular epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, SERPINF1, and TIMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelial cell differentiation activity versus SYNPO in UCEC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO →	+0.312	+0.056	.001	.006	3	8
BRCA	SERPINF1 →	+0.579	+0.038	<.001	<.001	3	7
BRCA	TIMP2 →	+0.711	+0.060	<.001	<.001	3	7
BRCA	TUBB6 →	+0.565	+0.067	<.001	<.001	3	7
UCEC	GUCY1B1 →	+0.502	+0.070	<.001	.008	3	7
LSCC	PHLDB1 →	+0.400	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072311 vs SYNPO — UCEC

Explore this scatter interactively →