Glomerular epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Glomerular epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXYD6, SNED1, and ADAM8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelial cell differentiation activity versus FXYD6 in CCRCC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FXYD6 →	+0.646	+0.289	<.001	.005	3	4
LSCC	SNED1 →	+0.455	+0.488	.003	<.001	3	4
COAD	ADAM8 →	+0.906	+0.578	<.001	.001	2	4
PDAC	CLEC11A →	+0.369	+0.596	.002	.001	3	3
PDAC	JOSD2 →	+0.229	+0.610	.008	.001	3	3
PDAC	KANK2 →	+0.342	+0.764	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072311 vs FXYD6 — CCRCC

Explore this scatter interactively →