Glomerular epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Glomerular epithelial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF3, MRGPRX2, and LMO7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF3 grouped by Glomerular epithelial cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARHGEF3 →	+0.282	+1.338	<.001	<.001	3	5
CNS	MRGPRX2 →	-0.313	-1.026	<.001	.001	3	5
LIVER	LMO7 →	-0.415	-1.418	.007	<.001	2	5
LUNG_NSCLC_LUSC	EDNRA →	-0.193	-1.105	.006	.005	3	4
BLOOD_Leukemia	TMED10 →	+0.178	+1.058	.001	.003	3	4
SOFT_TISSUE	SERPINC1 →	-0.263	-1.241	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF3 by Glomerular epithelial cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →