Glomerular epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Glomerular epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL, MT2A, and RRAS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelial cell differentiation activity versus PODXL in SOFT_TISSUE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PODXL →	+4.762	+0.659	.001	.001	2	10
OESOPHAGUS	MT2A →	+3.682	+0.374	.002	.002	3	7
OVARY	RRAS2 →	+1.170	+0.300	.001	.001	3	6
OVARY	EHD2 →	+3.286	+0.361	<.001	<.001	3	6
LUNG_SCLC	MYH9 →	+1.496	+0.393	.005	.001	3	5
OVARY	SERPINE1 →	+5.145	+0.421	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072311 vs PODXL — SOFT_TISSUE

Explore this scatter interactively →