Glomerular epithelial cell development

Across TCGA patient cohorts, RNA activity of the Glomerular epithelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSPT1, CYGB, and NDUFAF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelial cell development activity versus GSPT1 in BRCA (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GSPT1 →	-0.243	-0.079	.002	<.001	3	7
BRCA	CYGB →	+0.329	+0.044	.001	.004	3	6
LUAD	NDUFAF4 →	-0.373	-0.065	<.001	.001	3	6
LSCC	ARHGEF17 →	+0.210	+0.070	<.001	<.001	3	6
BRCA	RSU1 →	+0.461	+0.113	<.001	<.001	3	5
BRCA	TNS2_S102 →	+0.766	+0.089	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072310 vs GSPT1 — BRCA

Explore this scatter interactively →