Glomerular epithelial cell development

Across TCGA cell cohorts, RNA activity of the Glomerular epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4A, SNTB1, and EPB41L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA4A grouped by Glomerular epithelial cell development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEMA4A →	+4.019	+2.082	<.001	<.001	3	6
LUNG_NSCLC_LUAD	SNTB1 →	+1.448	+0.970	<.001	<.001	3	5
BLOOD_Leukemia	EPB41L2 →	-1.873	-1.034	.005	.002	3	5
LIVER	RPL11 →	-0.591	-1.475	.002	<.001	2	5
SOFT_TISSUE	BICD1 →	-1.770	-1.488	.004	<.001	3	4
SOFT_TISSUE	GPS1 →	-0.684	-1.343	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA4A by Glomerular epithelial cell development activity — URINARY_TRACT

Explore this box plot interactively →