Glomerular epithelial cell development

Across TCGA cell cohorts, RNA activity of the Glomerular epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODXL, SERPINE1, and MT2A, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glomerular epithelial cell development activity versus PODXL in SOFT_TISSUE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PODXL →	+4.717	+0.596	.002	.001	3	12
OVARY	SERPINE1 →	+3.836	+0.279	.003	.001	3	6
OVARY	MT2A →	+2.923	+0.256	.001	.001	3	6
BLOOD_Myeloma	ANO10 →	+1.924	+0.335	.001	.005	3	5
SOFT_TISSUE	ASPH →	+2.589	+0.533	.004	<.001	3	5
BREAST	TDG →	-0.512	-0.222	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072310 vs PODXL — SOFT_TISSUE

Explore this scatter interactively →