Metanephric S-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric S-shaped body morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRA1, LTBP2, and TLN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric S-shaped body morphogenesis activity versus SRA1 in LSCC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRA1 →	-0.173	-0.059	.001	.001	3	5
COAD	LTBP2 →	+0.487	+0.053	.002	.002	3	5
BRCA	TLN2 →	+0.390	+0.076	.005	.007	3	5
BRCA	WDR13 →	+0.207	+0.106	.006	.001	3	5
BRCA	DDX21_S89 →	-0.750	-0.076	<.001	<.001	3	5
OV	HMCN1 →	+0.585	+0.094	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072284 vs SRA1 — LSCC

Explore this scatter interactively →