Metanephric S-shaped body morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric S-shaped body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SBNO1-AS1, RPL35P1, and MIR4427, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric S-shaped body morphogenesis activity versus SBNO1-AS1 in BRCA (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SBNO1-AS1 →	+0.626	+0.188	<.001	.005	3	4
HNSC	RPL35P1 →	+1.355	+0.316	.001	.002	2	4
GBM	MIR4427 →	-0.854	-0.585	.007	.003	3	3
LUAD	RPL22P16 →	+0.415	+0.152	<.001	<.001	3	3
LUAD	RNA5SP460 →	-0.529	-0.111	<.001	.006	3	3
LUAD	ANP32BP1 →	+0.087	+0.182	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072284 vs SBNO1-AS1 — BRCA

Explore this scatter interactively →