Metanephric S-shaped body morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephric S-shaped body morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A39, RGP1, and LRRFIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A39 grouped by Metanephric S-shaped body morphogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC25A39 →	-0.880	-2.026	.002	.002	3	5
BLOOD_Lymphoma	RGP1 →	-0.611	-1.794	<.001	<.001	3	5
OESOPHAGUS	LRRFIP1 →	+0.942	+1.424	<.001	<.001	3	4
CNS	ARPC1B →	+2.173	+1.179	<.001	<.001	3	4
PANCREAS	STAG1 →	-0.673	-1.069	<.001	.005	3	4
PANCREAS	IQSEC2 →	+1.103	+1.228	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A39 by Metanephric S-shaped body morphogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →