Metanephric renal vesicle morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric renal vesicle morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALU, PLOD2, and SH3PXD2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric renal vesicle morphogenesis activity versus CALU in GBM (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CALU →	+0.325	+0.087	.004	<.001	3	7
GBM	PLOD2 →	+0.752	+0.082	<.001	.003	3	7
LUAD	SH3PXD2B →	+0.307	+0.088	<.001	<.001	3	6
LSCC	KIF26B_S1084 →	+1.187	+0.116	<.001	<.001	3	6
LSCC	P3H1 →	+0.495	+0.110	<.001	<.001	3	6
COAD	POSTN →	+0.725	+0.050	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072283 vs CALU — GBM

Explore this scatter interactively →