Metanephric renal vesicle morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric renal vesicle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPFIA2, SLC41A2, and GDAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric renal vesicle morphogenesis activity versus PPFIA2 in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPFIA2 →	-0.321	-0.354	.009	.004	3	3
CCRCC	SLC41A2 →	+0.515	+0.395	<.001	.005	2	4
LSCC	GDAP1 →	-0.454	-0.666	.002	.002	3	3
PDAC	GCOM1 →	-0.427	-0.565	.001	.005	3	3
LSCC	MSN →	+0.454	+0.475	.001	.008	3	3
PDAC	ANKRD18A →	-0.547	-0.726	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072283 vs PPFIA2 — CCRCC

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