Metanephric nephron tubule morphogenesis

Across TCGA cell cohorts, RNA activity of the Metanephric nephron tubule morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD15, PLAC9, and SLC48A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCTD15 grouped by Metanephric nephron tubule morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KCTD15 →	-3.053	-1.811	.001	.001	3	4
BREAST	PLAC9 →	+0.794	+0.548	.006	.008	3	4
URINARY_TRACT	SLC48A1 →	-1.215	-1.317	.007	.001	3	4
SKIN	JAK2 →	+0.811	+0.909	<.001	.003	3	4
LUNG_NSCLC_LUSC	C11orf45 →	+1.683	+0.960	.001	.006	3	4
LARGE_INTESTINE	TYW3 →	-0.792	-1.076	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCTD15 by Metanephric nephron tubule morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →