Metanephric nephron morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric nephron morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR19, PKD1P3, and RBMS2, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron morphogenesis activity versus WDR19 in DLBC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	WDR19 →	+1.074	+0.042	.002	.003	3	25
THYM	PKD1P3 →	+0.807	+0.057	<.001	<.001	3	25
THYM	RBMS2 →	+0.785	+0.041	<.001	<.001	3	25
THYM	FTX →	+0.701	+0.072	<.001	<.001	3	25
KIRP	STARD4-AS1 →	+0.882	+0.081	<.001	<.001	3	25
THYM	PKD1P6 →	+0.957	+0.059	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072273 vs WDR19 — DLBC

Explore this scatter interactively →