Metanephric nephron morphogenesis

Across TCGA patient cohorts, RNA activity of the Metanephric nephron morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCD2, C7, and COL1A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metanephric nephron morphogenesis activity versus SMARCD2 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMARCD2 →	-0.268	-0.056	<.001	.001	3	6
OV	C7 →	+0.887	+0.061	.001	.002	3	6
LSCC	COL1A2 →	+0.613	+0.047	<.001	.002	3	6
LSCC	PCOLCE →	+0.657	+0.051	<.001	<.001	3	6
UCEC	PHLDA1 →	+0.800	+0.084	<.001	<.001	3	5
PDAC	PPIF →	-0.255	-0.042	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072273 vs SMARCD2 — LSCC

Explore this scatter interactively →